Probiotics for preventing children’s antibiotic-associated diarrhoea

To date, antibiotics have been one of the most frequently prescribed medications for children. Despite being a life-saving medication, antibiotics have a common and unpleasant side effect, namely antibiotic-associated diarrhoea (AAD). It is estimated that up to 20% of children develop diarrhoea after antibiotic treatment.  

Role of Ecologic® AAD 612 in preventing AAD in children 

Probiotics, such as Ecologic® AAD, are effective in preventing AAD in adults. However, since AAD differs between adults and children, Winclove Probiotics have recently opted to assess the efficacy of a slightly modified version of our best-selling multispecies probiotic formulation, Ecologic® AAD (Ecologic® AAD 612), in terms of its efficacy in preventing AAD among a paediatric population. The study was carried out between 2018 and 2021, and its outcomes are recently published at JAMA Pediatrics. This multicentre study was performed in collaboration with internationally renowned researchers and paediatricians, Prof. Hania Szajewska in Warsaw, Poland and Dr. Tim de Meij in Amsterdam, the Netherlands. 

More information

This is the largest multicentre RCT ever performed by Winclove and provides valuable outcomes on the role of Ecologic® AAD 612 in children. The formulation showed to be very effective in preventing diarrhoea during and after antibiotic use in children. In addition, there are good indications for the broadening of its potential, for example in preventing rotaviral diarrhoea and the consequent need for rehydration therapy. 

If you have any questions or would like to know more about this study or Ecologic® AAD, reach out to your account manager.

doi:10.1001/jamapediatrics.2022.1973